diff --git a/buildroot/bin/__init__.py b/buildroot/bin/__init__.py
new file mode 100644
index 0000000000..e69de29bb2
diff --git a/buildroot/bin/config.py b/buildroot/bin/config.py
new file mode 100755
index 0000000000..b1a67ad965
--- /dev/null
+++ b/buildroot/bin/config.py
@@ -0,0 +1,96 @@
+'''
+config.py - Helper functions for config manipulation
+'''
+import re
+
+FILES = ('Marlin/Configuration.h', 'Marlin/Configuration_adv.h')
+
+def set(file_path, define_name, value):
+    '''
+    Replaces a define in a file with a new value.
+    Returns True if the define was found and replaced, False otherwise.
+    '''
+    # Read the contents of the file
+    with open(file_path, 'r') as f:
+        content = f.readlines()
+
+    modified = False
+    for i in range(len(content)):
+        # Regex to match the desired pattern
+        match = re.match(r'^(\s*)(/*)(\s*)(#define\s+{})\s+(.*)$'.format(re.escape(define_name)), content[i])
+        if match:
+            new_line = f"{match[1]}{match[3]}{match[4]} {value} // {match[5]}\n"
+            content[i] = new_line
+            modified = True
+
+    # Write the modified content back to the file only if changes were made
+    if modified:
+        with open(file_path, 'w') as f:
+            f.writelines(content)
+        return True
+
+    return False
+
+def add(file_path, define_name, value=""):
+    '''
+    Insert a define on the first blank line in a file.
+    Returns True if the define was found and replaced, False otherwise.
+    '''
+    with open(file_path, 'r') as f:
+        content = f.readlines()
+
+    # Prepend a space to the value if it's not empty
+    if value != "":
+        value = " " + value
+
+    # Find the first blank line to insert the new define
+    for i in range(len(content)):
+        if content[i].strip() == '':
+            # Insert the define at the first blank line
+            content.insert(i, f"#define {define_name}{value}\n")
+            break
+    else:
+        # If no blank line is found, append to the end
+        content.append(f"#define {define_name}{value}\n")
+
+    with open(file_path, 'w') as f:
+        f.writelines(content)
+
+def enable(file_path, define_name, enable=True):
+    '''
+    Uncomment or comment the named defines in the given file path.
+    Returns True if the define was found, False otherwise.
+    '''
+    # Read the contents of the file
+    with open(file_path, 'r') as f:
+        content = f.readlines()
+
+    # Prepare the regex
+    regex = re.compile(r'^(\s*)(/*)(\s*)(#define\s+{}\b.*?)( *//.*)?$'.format(re.escape(define_name)))
+
+    # Find the define in the file and uncomment or comment it
+    found = False
+    modified = False
+    for i in range(len(content)):
+        match = regex.match(content[i])
+        if not match: continue
+        found = True
+        if enable:
+            if match[2]:
+                modified = True
+                comment = '' if match[5] is None else '  ' + match[5]
+                content[i] = f"{match[1]}{match[3]}{match[4]}{comment}\n"
+        else:
+            if not match[2]:
+                modified = True
+                comment = '' if match[5] is None else match[5]
+                if comment.startswith('  '): comment = comment[2:]
+                content[i] = f"{match[1]}//{match[3]}{match[4]}{comment}\n"
+        break
+
+    # Write the modified content back to the file only if changes were made
+    if modified:
+        with open(file_path, 'w') as f:
+            f.writelines(content)
+
+    return found
diff --git a/buildroot/bin/opt_add b/buildroot/bin/opt_add
index 2306ebdaa1..3abe309ab6 100755
--- a/buildroot/bin/opt_add
+++ b/buildroot/bin/opt_add
@@ -1,3 +1,11 @@
-#!/usr/bin/env bash
+#!/usr/bin/env python
 
-eval "echo '#define ${@}' | cat - Marlin/Configuration.h > temp && mv temp Marlin/Configuration.h"
+import sys, config
+
+def main():
+    args = sys.argv[1:]
+    for name in args:
+        config.add(config.FILES[0], name)
+
+if __name__ == "__main__":
+    main()
diff --git a/buildroot/bin/opt_disable b/buildroot/bin/opt_disable
index 8b36bc1f34..9331b2c924 100755
--- a/buildroot/bin/opt_disable
+++ b/buildroot/bin/opt_disable
@@ -1,36 +1,21 @@
-#!/usr/bin/env bash
+#!/usr/bin/env python
 
-# exit on first failure
-set -e
+import sys, os,config
 
-# Get SED_CMD, SED_I, and the BSDSED flag
-. $(dirname $0)/opt_sed
+def main():
+    args = sys.argv[1:]
 
-for opt in "$@" ; do
-  DID=0 ; FOUND=0
-  for FN in Marlin/Configuration.h Marlin/Configuration_adv.h; do
-    if [[ $BSDSED ]]; then
-      # BSD sed version (macOS)
-      "${SED_CMD}" "${SED_I[@]}" \
-        "/^[[:space:]]*#define[[:space:]]+${opt}\b/{
-          s/^[[:space:]]*\(#define[[:space:]]+${opt}\b.*\)/\/\/\1/
-          h
-          \$b end
-        }
-        \$!b
-        :end
-        x
-        /./{ x; q0; }
-        x
-        q1" \
-        $FN && DID=1
-    else
-      # GNU sed version
-      "${SED_CMD}" "${SED_I[@]}" \
-        "/^\(\s*\)\(#define\s\+${opt}\b\s\?\)\(\s\s\)\?/{s//\1\/\/\2/;h};\${x;/./{x;q0};x;q1}" \
-        $FN && DID=1
-    fi
-    ((DID||FOUND)) || { grep -E "^\s*\/\/#define\s+${opt}\b" $FN >/dev/null && FOUND=1 ; }
-  done
-  ((DID||FOUND)) || (echo "ERROR: $(basename $0) Can't find ${opt}" >&2 && exit 9)
-done
+    for name in args:
+        changed = False
+
+        for file in config.FILES:
+            if os.path.exists(file):
+                if config.enable(file, name, False):
+                    changed = True
+
+        if not changed:
+            print(f"ERROR: Can't find {name}")
+            exit(1)
+
+if __name__ == "__main__":
+    main()
diff --git a/buildroot/bin/opt_enable b/buildroot/bin/opt_enable
index 292b4952d7..fd5c3a1b4b 100755
--- a/buildroot/bin/opt_enable
+++ b/buildroot/bin/opt_enable
@@ -1,36 +1,21 @@
-#!/usr/bin/env bash
+#!/usr/bin/env python
 
-# exit on first failure
-set -e
+import sys, os,config
 
-# Get SED_CMD, SED_I, and the BSDSED flag
-. $(dirname $0)/opt_sed
+def main():
+    args = sys.argv[1:]
 
-for opt in "$@" ; do
-  DID=0 ; FOUND=0
-  for FN in Marlin/Configuration.h Marlin/Configuration_adv.h; do
-    if [[ $BSDSED ]]; then
-      # BSD sed version (macOS)
-      "${SED_CMD}" "${SED_I[@]}" \
-        "/^[[:space:]]*\/\/[[:space:]]*#define[[:space:]]+${opt}\b/{
-          s/^[[:space:]]*\/\/[[:space:]]*\(#define[[:space:]]+${opt}\b\)[[:space:]]*/\1   /
-          h
-          \$b end
-        }
-        \$!b
-        :end
-        x
-        /./{ x; q0; }
-        x
-        q1" \
-        $FN && DID=1
-    else
-      # GNU sed version
-      "${SED_CMD}" "${SED_I[@]}" \
-        "/^\(\s*\)\/\/\(\s*\)\(#define\s\+${opt}\b\)\( \?\)/{s//\1\2\3\4\4\4/;h};\${x;/./{x;q0};x;q1}" \
-        $FN && DID=1
-    fi
-    ((DID||FOUND)) || { grep -E "^\s*#define\s+${opt}\b" $FN >/dev/null && FOUND=1 ; }
-  done
-  ((DID||FOUND)) || (echo "ERROR: $(basename $0) Can't find ${opt}" >&2 && exit 9)
-done
+    for name in args:
+        changed = False
+
+        for file in config.FILES:
+            if os.path.exists(file):
+                if config.enable(file, name):
+                    changed = True
+
+        if not changed:
+            print(f"ERROR: Can't find {name}")
+            exit(1)
+
+if __name__ == "__main__":
+    main()
diff --git a/buildroot/bin/opt_sed b/buildroot/bin/opt_sed
deleted file mode 100755
index d6075add01..0000000000
--- a/buildroot/bin/opt_sed
+++ /dev/null
@@ -1,9 +0,0 @@
-# Detect sed version
-SED_CMD="sed"
-SED_I=(-i)
-if command -v gsed >/dev/null 2>&1; then
-  SED_CMD="gsed"
-elif [[ "$(uname)" == "Darwin" ]]; then
-  SED_I=(-i '')
-  BSDSED=1
-fi
diff --git a/buildroot/bin/opt_set b/buildroot/bin/opt_set
index d58cfc3d14..cf8bbb9449 100755
--- a/buildroot/bin/opt_set
+++ b/buildroot/bin/opt_set
@@ -1,38 +1,25 @@
-#!/usr/bin/env bash
+#!/usr/bin/env python
 
-# exit on first failure
-set -e
+import sys, os, config
 
-# Get SED_CMD, SED_I, and the BSDSED flag
-. $(dirname $0)/opt_sed
+def main():
+    args = sys.argv[1:]
+    if len(args) % 2 != 0:
+        print("ERROR: Please provide pairs of <name> <value>")
+        return
 
-while [[ $# > 1 ]]; do
-  DID=0
-  for FN in Marlin/Configuration.h Marlin/Configuration_adv.h; do
-    if [[ $BSDSED ]]; then
-      # BSD sed version (macOS)
-      $SED_CMD "${SED_I[@]}" \
-        "/^[[:space:]]*\/\{0,2\}[[:space:]]*#define[[:space:]]+${1}\b/{
-          s/^[[:space:]]*\/\{0,2\}[[:space:]]*\(#define[[:space:]]+${1}\b\)[[:space:]]*.*/\1 ${2} \/\/ &/
-          h
-          \$b end
-        }
-        \$!b
-        :end
-        x
-        /./{ x; q0; }
-        x
-        q1" \
-        $FN && DID=1
-    else
-      # GNU sed version
-      $SED_CMD "${SED_I[@]}" \
-        "/^\(\s*\)\/\{0,2\}\s*\(#define\s\+${1}\b\)\s*\(.*\)$/{s//\1\2 ${2} \/\/ \3/;h};\${x;/./{x;q0};x;q1}" \
-        $FN && DID=1
-    fi
-  done
-  ((DID)) ||
-    eval "echo '#define ${1} ${2}' >>Marlin/Configuration.h" ||
-      (echo "ERROR: opt_set Can't set or add ${1}" >&2 && exit 9)
-  shift 2
-done
+    for i in range(0, len(args), 2):
+        name = args[i]
+        value = args[i + 1]
+        changed = False
+
+        for file in config.FILES:
+            if os.path.exists(file):
+                if config.set(file, name, value):
+                    changed = True
+
+        if not changed:
+            config.add(config.FILES[0], name, value)
+
+if __name__ == "__main__":
+    main()