diff --git a/Marlin/src/core/boards.h b/Marlin/src/core/boards.h
index f4db7b0c57..09b0eada1a 100644
--- a/Marlin/src/core/boards.h
+++ b/Marlin/src/core/boards.h
@@ -141,6 +141,8 @@
#define BOARD_EINSTART_S 1319 // Einstart retrofit
#define BOARD_WANHAO_ONEPLUS 1320 // Wanhao 0ne+ i3 Mini
#define BOARD_LEAPFROG_XEED2015 1321 // Leapfrog Xeed 2015
+#define BOARD_PICA_REVB 1322 // PICA Shield (original version)
+#define BOARD_PICA 1323 // PICA Shield (rev C or later)
//
// ATmega1281, ATmega2561
diff --git a/Marlin/src/pins/mega/pins_PICA.h b/Marlin/src/pins/mega/pins_PICA.h
new file mode 100644
index 0000000000..7771d5887f
--- /dev/null
+++ b/Marlin/src/pins/mega/pins_PICA.h
@@ -0,0 +1,143 @@
+/**
+ * Marlin 3D Printer Firmware
+ * Copyright (c) 2020 MarlinFirmware [https://github.com/MarlinFirmware/Marlin]
+ *
+ * Based on Sprinter and grbl.
+ * Copyright (c) 2011 Camiel Gubbels / Erik van der Zalm
+ *
+ * This program is free software: you can redistribute it and/or modify
+ * it under the terms of the GNU General Public License as published by
+ * the Free Software Foundation, either version 3 of the License, or
+ * (at your option) any later version.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+ * GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with this program. If not, see .
+ *
+ */
+
+/**
+ * Arduino Mega with PICA pin assignments
+ *
+ * PICA is Power, Interface, and Control Adapter and is open source hardware.
+ * See https://github.com/mjrice/PICA for schematics etc.
+ *
+ * Applies to PICA, PICA_REVB
+ */
+
+#ifndef BOARD_NAME
+ #define BOARD_NAME "PICA"
+#endif
+
+/*
+// Note that these are the "pins" that correspond to the analog inputs on the arduino mega.
+// These are not the same as the physical pin numbers
+ AD0 = 54; AD1 = 55; AD2 = 56; AD3 = 57;
+ AD4 = 58; AD5 = 59; AD6 = 60; AD7 = 61;
+ AD8 = 62; AD9 = 63; AD10 = 64; AD11 = 65;
+ AD12 = 66; AD13 = 67; AD14 = 68; AD15 = 69;
+*/
+
+#if !defined(__AVR_ATmega1280__) && !defined(__AVR_ATmega2560__)
+ #error "Oops! Make sure you have 'Arduino Mega' selected from the 'Tools -> Boards' menu."
+#endif
+
+//
+// Limit Switches
+//
+#define X_MIN_PIN 14
+#define X_MAX_PIN 15
+#define Y_MIN_PIN 16
+#define Y_MAX_PIN 17
+#define Z_MIN_PIN 23
+#define Z_MAX_PIN 22
+
+//
+// Steppers
+//
+#define X_STEP_PIN 55
+#define X_DIR_PIN 54
+#define X_ENABLE_PIN 60
+
+#define Y_STEP_PIN 57
+#define Y_DIR_PIN 56
+#define Y_ENABLE_PIN 61
+
+#define Z_STEP_PIN 59
+#define Z_DIR_PIN 58
+#define Z_ENABLE_PIN 62
+
+#define E0_STEP_PIN 67
+#define E0_DIR_PIN 24
+#define E0_ENABLE_PIN 26
+
+//
+// Temperature Sensors
+//
+#define TEMP_0_PIN 9 // Analog Input
+#define TEMP_1_PIN 10
+#define TEMP_BED_PIN 10
+#define TEMP_2_PIN 11
+#define TEMP_3_PIN 12
+
+//
+// Heaters / Fans
+//
+#ifndef HEATER_0_PIN
+ #define HEATER_0_PIN 10 // E0
+#endif
+#ifndef HEATER_1_PIN
+ #define HEATER_1_PIN 2 // E1
+#endif
+#define HEATER_BED_PIN 8 // HEAT-BED
+
+#ifndef FAN_PIN
+ #define FAN_PIN 9
+#endif
+#ifndef FAN_2_PIN
+ #define FAN_2_PIN 7
+#endif
+
+#define SDPOWER_PIN -1
+#define LED_PIN -1
+#define PS_ON_PIN -1
+#define KILL_PIN -1
+
+#define SSR_PIN 6
+
+// SPI for Max6675 or Max31855 Thermocouple
+#if DISABLED(SDSUPPORT)
+ #define MAX6675_SS_PIN 66 // Don't use 53 if using Display/SD card
+#else
+ #define MAX6675_SS_PIN 66 // Don't use 49 (SD_DETECT_PIN)
+#endif
+
+//
+// SD Support
+//
+#define SD_DETECT_PIN 49
+#define SDSS 53
+
+//
+// LCD / Controller
+//
+#define BEEPER_PIN 29
+
+#if HAS_SPI_LCD
+ #define LCD_PINS_RS 33
+ #define LCD_PINS_ENABLE 30
+ #define LCD_PINS_D4 35
+ #define LCD_PINS_D5 32
+ #define LCD_PINS_D6 37
+ #define LCD_PINS_D7 36
+
+ #define BTN_EN1 47
+ #define BTN_EN2 48
+ #define BTN_ENC 31
+
+ #define LCD_SDSS 53
+#endif
diff --git a/Marlin/src/pins/mega/pins_PICAOLD.h b/Marlin/src/pins/mega/pins_PICAOLD.h
new file mode 100644
index 0000000000..88fa1ada29
--- /dev/null
+++ b/Marlin/src/pins/mega/pins_PICAOLD.h
@@ -0,0 +1,28 @@
+/**
+ * Marlin 3D Printer Firmware
+ * Copyright (c) 2020 MarlinFirmware [https://github.com/MarlinFirmware/Marlin]
+ *
+ * Based on Sprinter and grbl.
+ * Copyright (c) 2011 Camiel Gubbels / Erik van der Zalm
+ *
+ * This program is free software: you can redistribute it and/or modify
+ * it under the terms of the GNU General Public License as published by
+ * the Free Software Foundation, either version 3 of the License, or
+ * (at your option) any later version.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
+ * GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with this program. If not, see .
+ *
+ */
+
+#define HEATER_0_PIN 9 // E0
+#define HEATER_1_PIN 10 // E1
+#define FAN_PIN 11
+#define FAN2_PIN 12
+
+#include "pins_PICA.h"
diff --git a/Marlin/src/pins/pins.h b/Marlin/src/pins/pins.h
index 3b6b474bcf..ce03a3468d 100644
--- a/Marlin/src/pins/pins.h
+++ b/Marlin/src/pins/pins.h
@@ -252,6 +252,10 @@
#include "mega/pins_HJC2560C_REV2.h" // ATmega2560 env:megaatmega2560
#elif MB(LEAPFROG_XEED2015)
#include "mega/pins_LEAPFROG_XEED2015.h" // ATmega2560 env:megaatmega2560
+#elif MB(PICA)
+ #include "mega/pins_PICA.h" // ATmega2560 env:megaatmega2560
+#elif MB(PICA_REVB)
+ #include "mega/pins_PICAOLD.h" // ATmega2560 env:megaatmega2560
//
// ATmega1281, ATmega2561