diff --git a/src/libslic3r/PrintObject.cpp b/src/libslic3r/PrintObject.cpp
index 203f24d6d..683827501 100644
--- a/src/libslic3r/PrintObject.cpp
+++ b/src/libslic3r/PrintObject.cpp
@@ -567,12 +567,18 @@ bool PrintObject::invalidate_state_by_config_options(const std::vector<t_config_
             || opt_key == "dont_support_bridges"
             || opt_key == "first_layer_extrusion_width") {
             steps.emplace_back(posSupportMaterial);
+        } else if (opt_key == "bottom_solid_layers") {
+            steps.emplace_back(posPrepareInfill);
+            if(m_print->config().spiral_vase) {
+                // Changing the number of bottom layers when a spiral vase is enabled requires re-slicing the object again.
+                // Otherwise, holes in the bottom layers could be filled, as is reported in GH #5528.
+                steps.emplace_back(posSlice);
+            }
         } else if (
                opt_key == "interface_shells"
             || opt_key == "infill_only_where_needed"
             || opt_key == "infill_every_layers"
             || opt_key == "solid_infill_every_layers"
-            || opt_key == "bottom_solid_layers"
             || opt_key == "bottom_solid_min_thickness"
             || opt_key == "top_solid_layers"
             || opt_key == "top_solid_min_thickness"