diff --git a/CMakeLists.txt b/CMakeLists.txt
index 43d7dee70..b5f7cdec2 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -42,6 +42,21 @@ message("PATH: $ENV{PATH}")
 message("PERL5LIB: $ENV{PERL5LIB}")
 find_package(Perl REQUIRED)
 
+# CMAKE_PREFIX_PATH is used to point CMake to the remaining dependencies (Boost, TBB, ...)
+# We pick it from environment if it is not defined in another way
+if(NOT DEFINED CMAKE_PREFIX_PATH)
+	if(DEFINED ENV{CMAKE_PREFIX_PATH})
+		set(CMAKE_PREFIX_PATH "$ENV{CMAKE_PREFIX_PATH}")
+	endif()
+endif()
+
+if (MSVC)
+	# By default the startup project in MSVC is the 'ALL_BUILD' cmake-created project,
+	# but we want 'slic3r' as the startup one because debugging run command is associated with it.
+	# (Unfortunatelly it cannot be associated with ALL_BUILD using CMake.)
+	set_property(DIRECTORY ${CMAKE_CURRENT_SOURCE_DIR} PROPERTY VS_STARTUP_PROJECT slic3r)
+endif ()
+
 add_subdirectory(xs)
 
 enable_testing ()
diff --git a/cmake/msvc/slic3r.wperl64d.props b/cmake/msvc/slic3r.wperl64d.props
new file mode 100644
index 000000000..68dac2085
--- /dev/null
+++ b/cmake/msvc/slic3r.wperl64d.props
@@ -0,0 +1,9 @@
+<?xml version="1.0" encoding="utf-8"?>
+<Project ToolsVersion="12.0" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+  <PropertyGroup>
+    <LocalDebuggerCommand>C:\wperl64d\bin\perl.exe</LocalDebuggerCommand>
+    <LocalDebuggerCommandArguments>slic3r.pl</LocalDebuggerCommandArguments>
+    <DebuggerFlavor>WindowsLocalDebugger</DebuggerFlavor>
+    <LocalDebuggerWorkingDirectory>..\..</LocalDebuggerWorkingDirectory>
+  </PropertyGroup>
+</Project>
diff --git a/cmake/msvc/xs.wperl64d.props b/cmake/msvc/xs.wperl64d.props
new file mode 100644
index 000000000..101923581
--- /dev/null
+++ b/cmake/msvc/xs.wperl64d.props
@@ -0,0 +1,11 @@
+<?xml version="1.0" encoding="utf-8"?>
+<Project ToolsVersion="12.0" xmlns="http://schemas.microsoft.com/developer/msbuild/2003">
+  <ImportGroup Label="PropertySheets">
+  </ImportGroup>
+  <PropertyGroup Label="UserMacros" />
+  <PropertyGroup>
+    <ExecutablePath>$(VC_ExecutablePath_x64);$(WindowsSDK_ExecutablePath);$(VS_ExecutablePath);$(MSBuild_ExecutablePath);$(FxCopDir);$(PATH);c:\wperl64d\bin\;</ExecutablePath>
+  </PropertyGroup>
+  <ItemDefinitionGroup />
+  <ItemGroup />
+</Project>
diff --git a/xs/CMakeLists.txt b/xs/CMakeLists.txt
index d2f252030..e4e0e1c6c 100644
--- a/xs/CMakeLists.txt
+++ b/xs/CMakeLists.txt
@@ -603,6 +603,17 @@ elseif (NOT MSVC)
     target_link_libraries(slic3r -lstdc++)
 endif ()
 
+if (MSVC)
+    # Here we associate some additional properties with the MSVC projects to enable compilation and debugging out of the box.
+    # It seems a props file needs to be copied to the same dir as the proj file, otherwise MSVC doesn't load it up.
+    # For copying, the configure_file() function seems to work much better than the file() function.
+    configure_file("${PROJECT_SOURCE_DIR}/cmake/msvc/xs.wperl64d.props" ${CMAKE_CURRENT_BINARY_DIR} COPYONLY)
+    set_target_properties(XS PROPERTIES VS_USER_PROPS "xs.wperl64d.props")
+    configure_file("${PROJECT_SOURCE_DIR}/cmake/msvc/slic3r.wperl64d.props" ${CMAKE_CURRENT_BINARY_DIR} COPYONLY)
+    set_target_properties(slic3r PROPERTIES VS_USER_PROPS "slic3r.wperl64d.props")
+endif ()
+
+
 # Installation
 install(TARGETS XS DESTINATION lib/slic3r-prusa3d/auto/Slic3r/XS)
 install(FILES lib/Slic3r/XS.pm DESTINATION lib/slic3r-prusa3d/Slic3r)
diff --git a/xs/src/xsinit.h b/xs/src/xsinit.h
index 49981b74b..96c4b74d7 100644
--- a/xs/src/xsinit.h
+++ b/xs/src/xsinit.h
@@ -59,6 +59,15 @@ extern "C" {
     #undef seek
     #undef send
     #undef write
+    #undef open
+    #undef close
+    #undef seekdir
+    #undef setbuf
+    #undef fread
+    #undef fseek
+    #undef fputc
+    #undef fwrite
+    #undef fclose
 #endif /* _MSC_VER */
 }
 #endif