diff --git a/src/libslic3r/GCode.cpp b/src/libslic3r/GCode.cpp
index fab7a7058..830fff8f9 100644
--- a/src/libslic3r/GCode.cpp
+++ b/src/libslic3r/GCode.cpp
@@ -413,14 +413,11 @@ namespace Slic3r {
 
     std::string WipeTowerIntegration::prime(GCode& gcodegen)
     {
-        assert(m_layer_idx == 0);
         std::string gcode;
-
         for (const WipeTower::ToolChangeResult& tcr : m_priming) {
             if (! tcr.extrusions.empty())
                 gcode += append_tcr(gcodegen, tcr, tcr.new_tool);
         }
-
         return gcode;
     }
 
@@ -1243,18 +1240,30 @@ void GCode::_do_export(Print& print, FILE* file, ThumbnailsGeneratorCallback thu
                 bbox_print.merge(get_wipe_tower_extrusions_extents(print, twolayers_printz));
                 BoundingBoxf bbox_prime(get_wipe_tower_priming_extrusions_extents(print));
                 bbox_prime.offset(0.5f);
-                // Beep for 500ms, tone 800Hz. Yet better, play some Morse.
-                _write(file, this->retract());
-                _write(file, "M300 S800 P500\n");
-                if (bbox_prime.overlap(bbox_print)) {
-                    // Wait for the user to remove the priming extrusions, otherwise they would
-                    // get covered by the print.
-                    _write(file, "M1 Remove priming towers and click button.\n");
-                }
-                else {
-                    // Just wait for a bit to let the user check, that the priming succeeded.
-                    //TODO Add a message explaining what the printer is waiting for. This needs a firmware fix.
-                    _write(file, "M1 S10\n");
+                bool overlap = bbox_prime.overlap(bbox_print);
+
+                if (print.config().gcode_flavor == gcfMarlin) {
+                    _write(file, this->retract());
+                    _write(file, "M300 S800 P500\n"); // Beep for 500ms, tone 800Hz.
+                    if (overlap) {
+                        // Wait for the user to remove the priming extrusions.
+                        _write(file, "M1 Remove priming towers and click button.\n");
+                    } else {
+                        // Just wait for a bit to let the user check, that the priming succeeded.
+                        //TODO Add a message explaining what the printer is waiting for. This needs a firmware fix.
+                        _write(file, "M1 S10\n");
+                    }
+                } else {
+                    // This is not Marlin, M1 command is probably not supported.
+                    // (See https://github.com/prusa3d/PrusaSlicer/issues/5441.)
+                    if (overlap) {
+                        print.active_step_add_warning(PrintStateBase::WarningLevel::CRITICAL,
+                            L("Your print is very close to the priming regions. "
+                              "Make sure there is no collision."));
+                    } else {
+                        // Just continue printing, no action necessary.
+                    }
+
                 }
             }
             print.throw_if_canceled();